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Gene Information
Gene ID:25402
Full Name:caspase 3, apoptosis related cysteine protease
Organism:Rattus norvegicus (Rat)
Genetic Location:16q11
Physical Location:48944225-48962419 on NC_005115.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 836    Symbol (Name): CASP3 (caspase 3, apoptosis-related cysteine peptidase)
Ortholog Status:The human GeneID 836 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Casp3
Fold Change:-1.21
Dataset Information
Tissue:Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012922.2NP_037054.1NC_005115.2 range: 48944225..48962419, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentISS
GO:0005829cytosolCellular ComponentIMP (15248196)
GO:0008234cysteine-type peptidase activityMolecular FunctionIEA
GO:0030693caspase activityMolecular FunctionIEA
GO:0030693caspase activityMolecular FunctionIDA (15004018|17218406)
GO:0008233peptidase activityMolecular FunctionISS
GO:0030693caspase activityMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionISS
GO:0004861cyclin-dependent protein kinase inhibitor activityMolecular FunctionISS
GO:0016005phospholipase A2 activator activityMolecular FunctionIMP (12492473)
GO:0030216keratinocyte differentiationBiological ProcessISS
GO:0030264nuclear fragmentation during apoptosisBiological ProcessISS
GO:0030182neuron differentiationBiological ProcessIEP (15248196)
GO:0030889negative regulation of B cell proliferationBiological ProcessISS
GO:0043029T cell homeostasisBiological ProcessISS
GO:0043066negative regulation of apoptosisBiological ProcessISS
GO:0045165cell fate commitmentBiological ProcessISS
GO:0045736negative regulation of cyclin-dependent protein kinase activityBiological ProcessISS
GO:0045786negative regulation of cell cycleBiological ProcessISS
GO:0046007negative regulation of activated T cell proliferationBiological ProcessISS
GO:0009611response to woundingBiological ProcessISS
GO:0009411response to UVBiological ProcessISS
GO:0008631induction of apoptosis by oxidative stressBiological ProcessISS
GO:0001836release of cytochrome c from mitochondriaBiological ProcessISS
GO:0006309DNA fragmentation during apoptosisBiological ProcessISS
GO:0006508proteolysisBiological ProcessIDA (15004018|17218406)
GO:0006508proteolysisBiological ProcessIEA
GO:0006508proteolysisBiological ProcessISS
GO:0006915apoptosisBiological ProcessIEA
GO:0006915apoptosisBiological ProcessISS
GO:0006917induction of apoptosisBiological ProcessISS
GO:0006917induction of apoptosisBiological ProcessTAS (11773055)
GO:0007242intracellular signaling cascadeBiological ProcessIMP (12492473)
GO:0007507heart developmentBiological ProcessISS
GO:0007605sensory perception of soundBiological ProcessISS
GO:0001782B cell homeostasisBiological ProcessISS
GO:0008625induction of apoptosis via death domain receptorsBiological ProcessISS
GO:0051402neuron apoptosisBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:25402