ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

GABRA1

Full Name:

gamma-aminobutyric acid (GABA) A receptor, alpha 1

Alias:

ECA4|EJM

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

5q34-q35

Physical Location:

161206982-161258991 on NC_000005.8

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 14394 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

GABRA1

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Information

HuGE Navigator Dataset

Name:		HuGE Navigator
Method:		Literature data mining
Publication:		Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:		HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000806.5	NP_000797.2	NC_000005.8 range: 161206982..161258991

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0045211	postsynaptic membrane	Cellular Component	IEA
GO:0045202	synapse	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0005887	integral to plasma membrane	Cellular Component	TAS (2465923)
GO:0030054	cell junction	Cellular Component	IEA
GO:0031404	chloride ion binding	Molecular Function	IEA
GO:0030594	neurotransmitter receptor activity	Molecular Function	IEA
GO:0004890	GABA-A receptor activity	Molecular Function	TAS (2465923)
GO:0005254	chloride channel activity	Molecular Function	IEA
GO:0005230	extracellular ligand-gated ion channel activity	Molecular Function	IEA
GO:0005216	ion channel activity	Molecular Function	IEA
GO:0007214	gamma-aminobutyric acid signaling pathway	Biological Process	TAS (2465923)
GO:0006811	ion transport	Biological Process	IEA
GO:0006821	chloride transport	Biological Process	IEA