ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ADAM5P

Full Name:

ADAM metallopeptidase domain 5 pseudogene

Alias:

ADAM5|TMDCII

Organism:

Homo sapiens (Human)

Chromosome:

8

Genetic Location:

8p11.23

Physical Location:

39291338-39393901 on NC_000008.9

Gene Type:

pseudo

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene SNP Information

SNP	Abuser/Control Ratio	Cluster
rs3935233 dbSNP	0.84	35

Association Dataset

Name:		16894614
Method:		Association
Publication:		Johnson et al. Am J Med Genet B Neuropsychiatr Genet. (2006) Pooled association genome scanning for alcohol dependence using 104,268 SNPs: validation and use to identify alcoholism vulnerability loci in unrelated individuals from the collaborative study on the genetics of alcoholism. PubMed
Summary:		Association genome scanning can identify markers for the allelic variants that contribute to vulnerability to complex disorders, including alcohol dependence. To improve the power and feasibility of this approach, we report validation of 100k microarray-based allelic frequency assessments in pooled DNA samples. We then use this approach with unrelated alcohol-dependent versus control individuals sampled from pedigrees collected by the Collaborative Study on the Genetics of Alcoholism (COGA). Allele frequency differences between alcohol-dependent and control individuals are assessed in quadruplicate at 104,268 autosomal SNPs in pooled samples. One hundred eighty-eight SNPs provide (1) the largest allele frequency differences between dependent versus control individuals; (2) t values 3 for these differences; and (3) clustering, so that 51 relatively small chromosomal regions contain at least three SNPs that satisfy criteria 1 and 2 above (Monte Carlo P = 0.00034).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NR_001448.1	-	NC_000008.9 range: 39291338..39393901

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0004222	metalloendopeptidase activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0006508	proteolysis	Biological Process	IEA
GO:0007155	cell adhesion	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: