ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Asns

Full Name:

asparagine synthetase

Alias:

MGC93148

Organism:

Rattus norvegicus (Rat)

Chromosome:

Physical Location:

32758606-32776553 on NC_005103.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 440 Symbol (Name): ASNS (asparagine synthetase)

Ortholog Status:

The human GeneID 440 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Gene Information

Dataset Information

Name:		17517326
Method:		Microarray
Tissue:		Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:		The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_013079.2	NP_037211.2	NC_005103.2 range: 32758606..32776553, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005625	soluble fraction	Cellular Component	IEA
GO:0005625	soluble fraction	Cellular Component	ISS
GO:0004066	asparagine synthase (glutamine-hydrolyzing) activity	Molecular Function	IEA
GO:0004066	asparagine synthase (glutamine-hydrolyzing) activity	Molecular Function	ISS
GO:0004066	asparagine synthase (glutamine-hydrolyzing) activity	Molecular Function	TAS (7818476)
GO:0016874	ligase activity	Molecular Function	IEA
GO:0043066	negative regulation of apoptosis	Biological Process	ISS
GO:0042149	cellular response to glucose starvation	Biological Process	ISS
GO:0008652	amino acid biosynthetic process	Biological Process	IEA
GO:0008152	metabolic process	Biological Process	IEA
GO:0006541	glutamine metabolic process	Biological Process	IEA
GO:0006529	asparagine biosynthetic process	Biological Process	IEA
GO:0006520	amino acid metabolic process	Biological Process	IEP (7818476)
GO:0045931	positive regulation of mitotic cell cycle	Biological Process	ISS