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Gene Information
Gene ID:25612
Full Name:asparagine synthetase
Organism:Rattus norvegicus (Rat)
Physical Location:32758606-32776553 on NC_005103.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 440    Symbol (Name): ASNS (asparagine synthetase)
Ortholog Status:The human GeneID 440 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Asns
Fold Change:1.25
Gene Information
Original ID1:Asns
Fold Change:1.2
Dataset Information
Tissue:Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_013079.2NP_037211.2NC_005103.2 range: 32758606..32776553, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005625soluble fractionCellular ComponentIEA
GO:0005625soluble fractionCellular ComponentISS
GO:0004066asparagine synthase (glutamine-hydrolyzing) activityMolecular FunctionIEA
GO:0004066asparagine synthase (glutamine-hydrolyzing) activityMolecular FunctionISS
GO:0004066asparagine synthase (glutamine-hydrolyzing) activityMolecular FunctionTAS (7818476)
GO:0016874ligase activityMolecular FunctionIEA
GO:0043066negative regulation of apoptosisBiological ProcessISS
GO:0042149cellular response to glucose starvationBiological ProcessISS
GO:0008652amino acid biosynthetic processBiological ProcessIEA
GO:0008152metabolic processBiological ProcessIEA
GO:0006541glutamine metabolic processBiological ProcessIEA
GO:0006529asparagine biosynthetic processBiological ProcessIEA
GO:0006520amino acid metabolic processBiological ProcessIEP (7818476)
GO:0045931positive regulation of mitotic cell cycleBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:25612