ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

25675

Symbol:

Hmgcr

Full Name:

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

Alias:

3H3M

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

2q12

Physical Location:

27127503-27149579 on NC_005101.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3156 Symbol (Name): HMGCR (3-hydroxy-3-methylglutaryl-Coenzyme A reductase)

Ortholog Status:

The human GeneID 3156 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hmgcr
Fold Change:		-1.28
Tissue:		Amygdala

Dataset Information

Name:		17517326
Method:		Microarray
Tissue:		Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:		The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_013134.2	NP_037266.2	NC_005101.2 range: 27127503..27149579, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005792	microsome	Cellular Component	ISS
GO:0016020	membrane	Cellular Component	IEA
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA
GO:0005792	microsome	Cellular Component	IDA (12841361)
GO:0005792	microsome	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0042282	hydroxymethylglutaryl-CoA reductase activity	Molecular Function	IDA (12841361)
GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	Molecular Function	IEA
GO:0042803	protein homodimerization activity	Molecular Function	IDA (4019513)
GO:0050661	NADP binding	Molecular Function	IEA
GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	Molecular Function	ISS
GO:0008542	visual learning	Biological Process	IEA
GO:0043407	negative regulation of MAP kinase activity	Biological Process	ISS
GO:0043407	negative regulation of MAP kinase activity	Biological Process	IEA
GO:0006695	cholesterol biosynthetic process	Biological Process	IDA (12841361)
GO:0006695	cholesterol biosynthetic process	Biological Process	IEA
GO:0006695	cholesterol biosynthetic process	Biological Process	ISS
GO:0008299	isoprenoid biosynthetic process	Biological Process	IEA
GO:0015936	coenzyme A metabolic process	Biological Process	IEA
GO:0010142	farnesyl diphosphate biosynthetic process, mevalonate pathway	Biological Process	TAS (12841361)
GO:0009790	embryonic development	Biological Process	ISS
GO:0009790	embryonic development	Biological Process	IEA
GO:0008542	visual learning	Biological Process	ISS