ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

GALNT8

Full Name:

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)

Alias:

GALNAC-T8

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

12p13.3

Physical Location:

4700012-4752152 on NC_000012.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D12S99

5434815

Region:		3434815-7434815
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_017417.1	NP_059113.1	NC_000012.10 range: 4700012..4752152

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000139	Golgi membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005887	integral to plasma membrane	Cellular Component	NR
GO:0005794	Golgi apparatus	Cellular Component	IEA
GO:0005624	membrane fraction	Cellular Component	NR
GO:0005529	sugar binding	Molecular Function	IEA
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	Molecular Function	TAS (10767557)
GO:0016757	transferase activity, transferring glycosyl groups	Molecular Function	IEA
GO:0030145	manganese ion binding	Molecular Function	IEA