ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Map2k1

Full Name:

mitogen-activated protein kinase kinase 1

Alias:

MAPKK1|MEKK1|Mek1|Prkmk1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

9 C|9 36.0 cM

Physical Location:

64033599-64101411 on NC_000075.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5604 Symbol (Name): MAP2K1 (mitogen-activated protein kinase kinase 1)

Ortholog Status:

The human GeneID 5604 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Map2k1
Fold Change:		0.67
Note:		Significantly regulated by ethanol in cortical neurons

Gene Information

Original ID1:		Map2k1
Fold Change:		0.66
Note:		Significantly regulated in cortical neurons treated with both ethanol and nicotine

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008927.3	NP_032953.1	NC_000075.5 range: 64033599..64101411, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0016301	kinase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004728	receptor signaling protein tyrosine phosphatase activity	Molecular Function	IMP (15896720)
GO:0004713	protein-tyrosine kinase activity	Molecular Function	IEA
GO:0004708	MAP kinase kinase activity	Molecular Function	IMP (11841548)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0004672	protein kinase activity	Molecular Function	IEA
GO:0043406	positive regulation of MAP kinase activity	Biological Process	IMP (15896720)
GO:0030216	keratinocyte differentiation	Biological Process	IMP (11841548)
GO:0030182	neuron differentiation	Biological Process	IMP (15145949)
GO:0006468	protein amino acid phosphorylation	Biological Process	IMP (15896720)
GO:0045597	positive regulation of cell differentiation	Biological Process	IDA (16908534)