ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Map2k4

Full Name:

mitogen-activated protein kinase kinase 4

Alias:

JNKK1|MEK4|MKK4|PRKMK4|Sek1|Serk1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

11 B3|11 33.0 cM

Physical Location:

65501745-65601798 on NC_000077.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6416 Symbol (Name): MAP2K4 (mitogen-activated protein kinase kinase 4)

Ortholog Status:

The human GeneID 6416 is also in human dataset(s).

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws4/Alcw3	Chronic Alcohol Withdrawal	11		15-36 (cM)	6.7	2.00E-07	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009157.4	NP_033183.1	NC_000077.5 range: 65501745..65601798, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0016301	kinase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (14500727)
GO:0004713	protein-tyrosine kinase activity	Molecular Function	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0004672	protein kinase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0000165	MAPKKK cascade	Biological Process	IPI (12556533)