ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

LHX6

Full Name:

LIM homeobox 6

Alias:

LHX6.1|MGC119542|MGC119544|MGC119545

Organism:

Homo sapiens (Human)

Chromosome:

9

Genetic Location:

9q33.2

Physical Location:

124004678-124030839 on NC_000009.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

LHX6

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D9S934

2.28

0.0006

120135477

D9S1682

2.33

0.0005

124033322

Region:		120135477-124033322
Phenotype:		ONSET (age at onset of AD)
Name:		17067344
Method:		Linkage
Publication:		Kuo et al. Alcohol Clin Exp Res. (2006) Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence. PubMed
Summary:		A 4-cM dense whole-genome linkage study was conducted in the Irish Affected Sib Pair Study of Alcohol Dependence. Probands, affected siblings, and parents were evaluated by structured interview. Variance component linkage analysis was applied to data from 485 families for 5 measures: initial sensitivity and tolerance (based on scales from the self-report of the effects of ethanol; maximum drinks within 24 hours, an empirically derived factor score based on withdrawal symptoms, and age at onset of alcohol dependence.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_014368.3	NP_055183.2	NC_000009.10 range: 124004678..124030839, complement
NM_199160.2	NP_954629.2	NC_000009.10 range: 124004678..124030839, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	TAS (10393337)
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0007420	brain development	Biological Process	TAS (10393337)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000106852

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: