ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

GCSH

Full Name:

glycine cleavage system protein H (aminomethyl carrier)

Alias:

GCE|NKH

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

16q23.2

Physical Location:

79673429-79687480 on NC_000016.8, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D16S516

77681517

Region:		75681517-79681517
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_004483.3	NP_004474.2	NC_000016.8 range: 79673429..79687480, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005739	mitochondrion	Cellular Component	TAS (3348809)
GO:0005960	glycine cleavage complex	Cellular Component	TAS (3348809)
GO:0004047	aminomethyltransferase activity	Molecular Function	TAS (3348809)
GO:0031405	lipoic acid binding	Molecular Function	IEA
GO:0006546	glycine catabolic process	Biological Process	TAS (1671321)