| Gene Information |
| Gene ID: | | 27123 |
| Symbol: | | DKK2 |
| Full Name: | | dickkopf homolog 2 (Xenopus laevis) |
| Alias: | | DKK-2 |
| Organism: | | Homo sapiens (Human) |
| Chromosome: | | 4 |
| Genetic Location: | | 4q25 |
| Physical Location: | | 108062407-108176901 on NC_000004.10, complement |
| Gene Type: | | protein-coding |
| Orthologs: | | This gene has no orthologs in other dataset(s). |
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| Gene in Ethanol Study Datasets |
| Linkage Dataset | | Marker | LOD | P value | Location (bp) | |
| D4S423 | 2.61 | 0.0003 | 92691777 | | D4S427 | 3.53 | 0.00003 | 121646580 | | Region: | | 92691777-121646580 | | Phenotype: | | ADSX (number of DSM-IV AD symptoms) | | Name: | | 16534506 | | Method: | | Linkage | | Publication: | | Prescott et al. Mol Psychiatry. (2006) Genomewide linkage study in the Irish affected sib pair study of alcohol dependence: evidence for a susceptibility region for symptoms of alcohol dependence on chromosome 4. PubMed | | Summary: | | We conducted a genome scan in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD). A 4 cM genome scan was conducted using 474 families of which most (96%) were comprised by affected sib pairs. Nonparametric and quantitative linkage analyses were conducted using DSM-IV alcohol dependence (AD) and number of DSM-IV AD symptoms (ADSX). Quantitative results indicate strong linkage for number of AD criteria to a broad region of chromosome 4, ranging from 4q22 to 4q32 (peak multipoint LOD=4.59, P=2.1 x 10(-6), at D4S1611). We got the gene list in the region between two markers D4S423 and D4S427 as markers between (included) these two markers have LOD scores >2 with P value <0.0003. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005576 | extracellular region | Cellular Component | IEA | |
| GO:0005615 | extracellular space | Cellular Component | TAS (10570958) | |
| GO:0007275 | multicellular organismal development | Biological Process | IEA | |
| GO:0030178 | negative regulation of Wnt receptor signaling pathway | Biological Process | IEA | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 27123 |
| HGNC: | | 2892 |
| Ensembl: | | ENSG00000155011 |
| MIM: | | 605415 |
| HPRD: | | 05658 |
| HuGE Navigator: | | 27123 |
| dbSNP: | | DKK2 |
| GeneCard: | | DKK2 |
| AceView: | | DKK2 |
