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Gene Information
Gene ID:27224
Symbol:Tceb3
Full Name:transcription elongation factor B (SIII), polypeptide 3
Alias:110kDa|AA408125|Tceb3a
Organism:Mus musculus (Mouse)
Chromosome:4
Genetic Location:4 D3
Physical Location:135559284-135577563 on NC_000070.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 6924    Symbol (Name): TCEB3 (transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A))
Ortholog Status:The human GeneID 6924 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Tceb3
Fold Change:1.29
Note:Significantly regulated in cortical neurons treated with both ethanol and nicotine
Dataset Information
Name:17295719
Method:Microarray
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_013736.4NP_038764.2NC_000070.5 range: 135559284..135577563, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0003677DNA bindingMolecular FunctionIEA
GO:0003746translation elongation factor activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIEA
GO:0030528transcription regulator activityMolecular FunctionIEA
GO:0006350transcriptionBiological ProcessIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0045449regulation of transcriptionBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:27224
MGI:
Ensembl:ENSMUSG00000028668
dbSNP:Tceb3
AceView:Tceb3