ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pdk4

Full Name:

pyruvate dehydrogenase kinase, isoenzyme 4

Alias:

AV005916

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

6 A1|6 0.63 cM

Physical Location:

5433350-5446277 on NC_000072.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5166 Symbol (Name): PDK4 (pyruvate dehydrogenase kinase, isozyme 4)

Ortholog Status:

The human GeneID 5166 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AJ001418
Fold Change:		1.6, 2.1, 1.7, 2.3
Note:		4 fold changes are from C57BL/6J trial 1, C57BL/6J trial 2, DBA/2J trial 1, DBA/2J trial 2

Dataset Information

Name:		15002731
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Acute ethanol response
Publication:		Treadwell et al. Neurochem Res. (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. PubMed
Summary:		We have analyzed the expression of approximately 24,000 genes using oligonucleotide microarrays to examine the brain expression profiles in two strains of inbred mice, C57BL/6J and DBA/2J, following exposure to an acute dose of ethanol. Our screen identified 61 genes responding to the ethanol treatment beyond a 1.5-fold threshold, with 46 genes altered in both mouse strains and 15 altered in only one strain.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_013743.2	NP_038771.1	NC_000072.5 range: 5433350..5446277, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005739	mitochondrion	Cellular Component	IDA (14651853)
GO:0005743	mitochondrial inner membrane	Cellular Component	IDA (12865426)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0016772	transferase activity, transferring phosphorus-containing groups	Molecular Function	IEA
GO:0000155	two-component sensor activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	Molecular Function	IEA
GO:0004712	protein serine/threonine/tyrosine kinase activity	Molecular Function	TAS (10548532)
GO:0004673	protein histidine kinase activity	Molecular Function	IEA
GO:0016301	kinase activity	Molecular Function	IEA
GO:0016310	phosphorylation	Biological Process	IEA
GO:0007165	signal transduction	Biological Process	IEA
GO:0006086	acetyl-CoA biosynthetic process from pyruvate	Biological Process	TAS (10548532)
GO:0006006	glucose metabolic process	Biological Process	IEA
GO:0005975	carbohydrate metabolic process	Biological Process	IEA
GO:0018106	peptidyl-histidine phosphorylation	Biological Process	IEA