Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:27273
Full Name:pyruvate dehydrogenase kinase, isoenzyme 4
Organism:Mus musculus (Mouse)
Genetic Location:6 A1|6 0.63 cM
Physical Location:5433350-5446277 on NC_000072.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 5166    Symbol (Name): PDK4 (pyruvate dehydrogenase kinase, isozyme 4)
Ortholog Status:The human GeneID 5166 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AJ001418
Fold Change:1.6, 2.1, 1.7, 2.3
Note:4 fold changes are from C57BL/6J trial 1, C57BL/6J trial 2, DBA/2J trial 1, DBA/2J trial 2
Dataset Information
Tissue:Whole brain
Phenotype:Acute ethanol response
Publication:Treadwell et al. Neurochem Res. (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. PubMed
Summary:We have analyzed the expression of approximately 24,000 genes using oligonucleotide microarrays to examine the brain expression profiles in two strains of inbred mice, C57BL/6J and DBA/2J, following exposure to an acute dose of ethanol. Our screen identified 61 genes responding to the ethanol treatment beyond a 1.5-fold threshold, with 46 genes altered in both mouse strains and 15 altered in only one strain.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_013743.2NP_038771.1NC_000072.5 range: 5433350..5446277, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005739mitochondrionCellular ComponentIDA (14651853)
GO:0005743mitochondrial inner membraneCellular ComponentIDA (12865426)
GO:0016740transferase activityMolecular FunctionIEA
GO:0016772transferase activity, transferring phosphorus-containing groupsMolecular FunctionIEA
GO:0000155two-component sensor activityMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0004740pyruvate dehydrogenase (acetyl-transferring) kinase activityMolecular FunctionIEA
GO:0004712protein serine/threonine/tyrosine kinase activityMolecular FunctionTAS (10548532)
GO:0004673protein histidine kinase activityMolecular FunctionIEA
GO:0016301kinase activityMolecular FunctionIEA
GO:0016310phosphorylationBiological ProcessIEA
GO:0007165signal transductionBiological ProcessIEA
GO:0006086acetyl-CoA biosynthetic process from pyruvateBiological ProcessTAS (10548532)
GO:0006006glucose metabolic processBiological ProcessIEA
GO:0005975carbohydrate metabolic processBiological ProcessIEA
GO:0018106peptidyl-histidine phosphorylationBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:27273