ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

GCLC

Full Name:

glutamate-cysteine ligase, catalytic subunit

Alias:

GCS|GLCL|GLCLC

Organism:

Homo sapiens (Human)

Chromosome:

6

Genetic Location:

6p12

Physical Location:

53470097-53517789 on NC_000006.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

GCLC

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001498.2	NP_001489.1	NC_000006.10 range: 53470097..53517789, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000287	magnesium ion binding	Molecular Function	IDA (24639)
GO:0004357	glutamate-cysteine ligase activity	Molecular Function	IDA (8104187\|11972604)
GO:0004357	glutamate-cysteine ligase activity	Molecular Function	IMP (16183645)
GO:0050662	coenzyme binding	Molecular Function	IPI (9675072\|9841880)
GO:0043531	ADP binding	Molecular Function	IDA (24639)
GO:0016874	ligase activity	Molecular Function	IEA
GO:0016595	glutamate binding	Molecular Function	IDA (9841880)
GO:0016481	negative regulation of transcription	Biological Process	IDA (10439045)
GO:0030503	regulation of cell redox homeostasis	Biological Process	IDA (10439045)
GO:0009725	response to hormone stimulus	Biological Process	IDA (8104187)
GO:0009408	response to heat	Biological Process	IDA (8104187)
GO:0006979	response to oxidative stress	Biological Process	IDA (10395918\|11972604)
GO:0006916	anti-apoptosis	Biological Process	IDA (10439045)
GO:0006750	glutathione biosynthetic process	Biological Process	IMP (12663448)
GO:0006750	glutathione biosynthetic process	Biological Process	IDA (8104187\|10395918)
GO:0006536	glutamate metabolic process	Biological Process	IDA (2294991\|12663448)
GO:0006534	cysteine metabolic process	Biological Process	IDA (2294991)
GO:0050880	regulation of blood vessel size	Biological Process	IMP (12598062)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000001084

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: