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Gene Information
Gene ID:2730
Symbol:GCLM
Full Name:glutamate-cysteine ligase, modifier subunit
Alias:GLCLR
Organism:Homo sapiens (Human)
Chromosome:1
Genetic Location:1p22.1
Physical Location:94125177-94147599 on NC_000001.9, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:GCLM
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_002061.2NP_002052.1NC_000001.9 range: 94125177..94147599, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005625soluble fractionCellular ComponentIDA (9675072)
GO:0005829cytosolCellular ComponentNAS (9895302)
GO:0004357glutamate-cysteine ligase activityMolecular FunctionIDA (9841880)
GO:0004357glutamate-cysteine ligase activityMolecular FunctionIMP (16183645)
GO:0005515protein bindingMolecular FunctionIPI (17353931)
GO:0035226glutamate-cysteine ligase catalytic subunit bindingMolecular FunctionIPI (9675072|9841880)
GO:0016874ligase activityMolecular FunctionIEA
GO:0016491oxidoreductase activityMolecular FunctionIEA
GO:0042493response to drugBiological ProcessIDA (9895302)
GO:0006979response to oxidative stressBiological ProcessIDA (10395918)
GO:0006750glutathione biosynthetic processBiological ProcessIMP (12081989)
GO:0006750glutathione biosynthetic processBiological ProcessIDA (10395918)
GO:0006536glutamate metabolic processBiological ProcessIDA (9841880|9895302)
GO:0050880regulation of blood vessel sizeBiological ProcessIMP (12975258)
Other Database Cross Links
NCBI Entrez Gene:2730
HGNC:4312
Ensembl:ENSG00000023909
MIM:601176
HPRD:03106
HuGE Navigator:2730
dbSNP:GCLM
GeneCard:GCLM
AceView:GCLM