ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

GCLM

Full Name:

glutamate-cysteine ligase, modifier subunit

Alias:

GLCLR

Organism:

Homo sapiens (Human)

Chromosome:

1

Genetic Location:

1p22.1

Physical Location:

94125177-94147599 on NC_000001.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

GCLM

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002061.2	NP_002052.1	NC_000001.9 range: 94125177..94147599, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005625	soluble fraction	Cellular Component	IDA (9675072)
GO:0005829	cytosol	Cellular Component	NAS (9895302)
GO:0004357	glutamate-cysteine ligase activity	Molecular Function	IDA (9841880)
GO:0004357	glutamate-cysteine ligase activity	Molecular Function	IMP (16183645)
GO:0005515	protein binding	Molecular Function	IPI (17353931)
GO:0035226	glutamate-cysteine ligase catalytic subunit binding	Molecular Function	IPI (9675072\|9841880)
GO:0016874	ligase activity	Molecular Function	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0042493	response to drug	Biological Process	IDA (9895302)
GO:0006979	response to oxidative stress	Biological Process	IDA (10395918)
GO:0006750	glutathione biosynthetic process	Biological Process	IMP (12081989)
GO:0006750	glutathione biosynthetic process	Biological Process	IDA (10395918)
GO:0006536	glutamate metabolic process	Biological Process	IDA (9841880\|9895302)
GO:0050880	regulation of blood vessel size	Biological Process	IMP (12975258)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000023909

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: