ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

GNA12

Full Name:

guanine nucleotide binding protein (G protein) alpha 12

Alias:

MGC104623|MGC99644|NNX3|RMP|gep

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

7p22.2

Physical Location:

2734264-2850484 on NC_000007.12, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D7S517

4464441

Region:		2464441-6464441
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007353.2	NP_031379.2	NC_000007.12 range: 2734264..2850484, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005886	plasma membrane	Cellular Component	EXP (10477691\|10648409\|11313914)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005525	GTP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (10026210)
GO:0004871	signal transducer activity	Molecular Function	NAS (8290554)
GO:0004871	signal transducer activity	Molecular Function	IEA
GO:0003924	GTPase activity	Molecular Function	TAS (8290554)
GO:0019001	guanyl nucleotide binding	Molecular Function	IEA
GO:0007165	signal transduction	Biological Process	IEA
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IEA
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	TAS (8290554)
GO:0007596	blood coagulation	Biological Process	TAS (8290554)