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Gene Information
Gene ID:2774
Symbol:GNAL
Full Name:guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
Organism:Homo sapiens (Human)
Chromosome:18
Genetic Location:18p11.22-p11.21
Physical Location:11679262-11871921 on NC_000018.8
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Linkage Dataset
MarkerLODP valueLocation (bp)
D18S53  11482730
Region:9482730-13482730
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Name:15211641
Method:Linkage
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_002071.2NP_002062.1NC_000018.8 range: 11679262..11871921
NM_182978.1NP_892023.1NC_000018.8 range: 11679262..11871921
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0003924GTPase activityMolecular FunctionTAS (8243272)
GO:0004871signal transducer activityMolecular FunctionIEA
GO:0005525GTP bindingMolecular FunctionIEA
GO:0019001guanyl nucleotide bindingMolecular FunctionIEA
GO:0007165signal transductionBiological ProcessIEA
GO:0007165signal transductionBiological ProcessTAS (8243272)
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:2774
HGNC:4388
Ensembl:ENSG00000141404
MIM:139312
HPRD:00758
HuGE Navigator:2774
dbSNP:GNAL
GeneCard:GNAL
AceView:GNAL