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Gene Information
Gene ID:2784
Symbol:GNB3
Full Name:guanine nucleotide binding protein (G protein), beta polypeptide 3
Organism:Homo sapiens (Human)
Chromosome:12
Genetic Location:12p13
Physical Location:6819635-6826817 on NC_000012.10
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:GNB3
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Information
Original IDNo. of PublicationsPhenotype
GNB31Alcoholism
GNB31Alcohol-Related Disorders
HuGE Navigator Dataset
Name:HuGE Navigator
Method:Literature data mining
Publication:Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.
Linkage Dataset
MarkerLODP valueLocation (bp)
D12S99  5434815
Region:3434815-7434815
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Name:15211641
Method:Linkage
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_002075.2NP_002066.1NC_000012.10 range: 6819635..6826817
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0003924GTPase activityMolecular FunctionTAS (9425898)
GO:0004871signal transducer activityMolecular FunctionIEA
GO:0007165signal transductionBiological ProcessIEA
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessTAS (2107550)
GO:0008217regulation of blood pressureBiological ProcessTAS (9425898)
GO:0009755hormone-mediated signalingBiological ProcessEXP (12626323)
Other Database Cross Links
NCBI Entrez Gene:2784
HGNC:4400
Ensembl:ENSG00000111664
MIM:139130
HPRD:00743
HuGE Navigator:2784
dbSNP:GNB3
GeneCard:GNB3
AceView:GNB3