| Gene Information |
| Gene ID: | | 2817 |
| Symbol: | | GPC1 |
| Full Name: | | glypican 1 |
| Alias: | | FLJ38078|glypican |
| Organism: | | Homo sapiens (Human) |
| Chromosome: | | 2 |
| Genetic Location: | | 2q35-q37 |
| Physical Location: | | 241023787-241056167 on NC_000002.10 |
| Gene Type: | | protein-coding |
| Orthologs: | | This gene has no orthologs in other dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | | Dataset Information | | Name: | | Literature Search | | Method: | | Literature search | | Summary: | | We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive. |
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| Linkage Dataset | | Marker | LOD | P value | Location (bp) | |
| D2S2973 | 2.20 | 0.0007 | 235696080 | | D2S140 | 1.95 | 0.0014 | 241388318 | | Region: | | 235696080-241388318 | | Phenotype: | | WDSFS (withdrawal symptoms factor score) | | Name: | | 17067344 | | Method: | | Linkage | | Publication: | | Kuo et al. Alcohol Clin Exp Res. (2006) Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence. PubMed | | Summary: | | A 4-cM dense whole-genome linkage study was conducted in the Irish Affected Sib Pair Study of Alcohol Dependence. Probands, affected siblings, and parents were evaluated by structured interview. Variance component linkage analysis was applied to data from 485 families for 5 measures: initial sensitivity and tolerance (based on scales from the self-report of the effects of ethanol; maximum drinks within 24 hours, an empirically derived factor score based on withdrawal symptoms, and age at onset of alcohol dependence. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005576 | extracellular region | Cellular Component | IEA | |
| GO:0005578 | proteinaceous extracellular matrix | Cellular Component | IEA | |
| GO:0005615 | extracellular space | Cellular Component | TAS (2148568) | |
| GO:0005886 | plasma membrane | Cellular Component | IEA | |
| GO:0005887 | integral to plasma membrane | Cellular Component | TAS (2148568) | |
| GO:0031225 | anchored to membrane | Cellular Component | IEA | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 2817 |
| HGNC: | | 4449 |
| Ensembl: | | ENSG00000063660 |
| MIM: | | 600395 |
| HPRD: | | 02671 |
| HuGE Navigator: | | 2817 |
| dbSNP: | | GPC1 |
| GeneCard: | | GPC1 |
| AceView: | | GPC1 |
