| Gene Information |
| Gene ID: | | 2825 |
| Symbol: | | GPR1 |
| Full Name: | | G protein-coupled receptor 1 |
| Organism: | | Homo sapiens (Human) |
| Chromosome: | | 2 |
| Genetic Location: | | 2q33.3 |
| Physical Location: | | 206748284-206791015 on NC_000002.10, complement |
| Gene Type: | | protein-coding |
| Orthologs: | | This gene has no orthologs in other dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | | Dataset Information | | Name: | | Literature Search | | Method: | | Literature search | | Summary: | | We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive. |
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| Linkage Dataset | | Marker | LOD | P value | Location (bp) | |
| D2S117 | | | 195326948 | | Region: | | 195326948-216757195 | | Phenotype: | | Alcoholism phenotype along with age, gender, and P300 or constraint | | Name: | | 15211641 | | Method: | | Linkage | | Publication: | | Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed | | Summary: | | A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb). |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005886 | plasma membrane | Cellular Component | IEA | |
| GO:0005887 | integral to plasma membrane | Cellular Component | TAS (7851889) | |
| GO:0001584 | rhodopsin-like receptor activity | Molecular Function | IEA | |
| GO:0004872 | receptor activity | Molecular Function | IEA | |
| GO:0007165 | signal transduction | Biological Process | IEA | |
| GO:0007186 | G-protein coupled receptor protein signaling pathway | Biological Process | TAS (7851889) | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 2825 |
| HGNC: | | 4463 |
| Ensembl: | | ENSG00000183671 |
| MIM: | | 600239 |
| HPRD: | | 02585 |
| HuGE Navigator: | | 2825 |
| dbSNP: | | GPR1 |
| GeneCard: | | GPR1 |
| AceView: | | GPR1 |
