ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

HEXDC

Full Name:

hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing

Alias:

FLJ23825

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17q25.3

Physical Location:

77969540-77993804 on NC_000017.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D17S928

77846128

Region:		75846128-78774742
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_173620.2	NP_775891.2	NC_000017.9 range: 77969540..77993804

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016798	hydrolase activity, acting on glycosyl bonds	Molecular Function	IEA
GO:0043169	cation binding	Molecular Function	IEA
GO:0005975	carbohydrate metabolic process	Biological Process	IEA
GO:0008152	metabolic process	Biological Process	IEA