ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Prps1

Full Name:

phosphoribosyl pyrophosphate synthetase 1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

Xq35

Physical Location:

128249845-128271890 on NC_005120.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5631 Symbol (Name): PRPS1 (phosphoribosyl pyrophosphate synthetase 1)

Ortholog Status:

The human GeneID 5631 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17517326
Method:		Microarray
Tissue:		Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:		The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_017243.2	NP_058939.1	NC_005120.2 range: 128249845..128271890

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0043234	protein complex	Cellular Component	IDA (2546925)
GO:0005625	soluble fraction	Cellular Component	IDA (2546925)
GO:0019003	GDP binding	Molecular Function	IDA (9748490)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0016301	kinase activity	Molecular Function	IEA
GO:0016208	AMP binding	Molecular Function	IDA (9748490)
GO:0000287	magnesium ion binding	Molecular Function	IDA (9748490)
GO:0005524	ATP binding	Molecular Function	IDA (2546925\|9748490)
GO:0005529	sugar binding	Molecular Function	IDA (2546925\|9748490)
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0004749	ribose phosphate diphosphokinase activity	Molecular Function	IDA (2546925\|9748490)
GO:0004749	ribose phosphate diphosphokinase activity	Molecular Function	IEA
GO:0006167	AMP biosynthetic process	Biological Process	IDA (2546925)
GO:0009165	nucleotide biosynthetic process	Biological Process	IEA
GO:0009165	nucleotide biosynthetic process	Biological Process	IDA (9748490)
GO:0009156	ribonucleoside monophosphate biosynthetic process	Biological Process	IEA
GO:0009116	nucleoside metabolic process	Biological Process	IEA