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Gene Information
Gene ID:29562
Full Name:phosphoribosyl pyrophosphate synthetase 1
Organism:Rattus norvegicus (Rat)
Genetic Location:Xq35
Physical Location:128249845-128271890 on NC_005120.2
Gene Type:protein-coding
Human Ortholog:GeneID: 5631    Symbol (Name): PRPS1 (phosphoribosyl pyrophosphate synthetase 1)
Ortholog Status:The human GeneID 5631 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Prps1
Fold Change:1.19
Dataset Information
Tissue:Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_017243.2NP_058939.1NC_005120.2 range: 128249845..128271890
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0043234protein complexCellular ComponentIDA (2546925)
GO:0005625soluble fractionCellular ComponentIDA (2546925)
GO:0019003GDP bindingMolecular FunctionIDA (9748490)
GO:0016740transferase activityMolecular FunctionIEA
GO:0016301kinase activityMolecular FunctionIEA
GO:0016208AMP bindingMolecular FunctionIDA (9748490)
GO:0000287magnesium ion bindingMolecular FunctionIDA (9748490)
GO:0005524ATP bindingMolecular FunctionIDA (2546925|9748490)
GO:0005529sugar bindingMolecular FunctionIDA (2546925|9748490)
GO:0000287magnesium ion bindingMolecular FunctionIEA
GO:0004749ribose phosphate diphosphokinase activityMolecular FunctionIDA (2546925|9748490)
GO:0004749ribose phosphate diphosphokinase activityMolecular FunctionIEA
GO:0006167AMP biosynthetic processBiological ProcessIDA (2546925)
GO:0009165nucleotide biosynthetic processBiological ProcessIEA
GO:0009165nucleotide biosynthetic processBiological ProcessIDA (9748490)
GO:0009156ribonucleoside monophosphate biosynthetic processBiological ProcessIEA
GO:0009116nucleoside metabolic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:29562