ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Btg2

Full Name:

B-cell translocation gene 2, anti-proliferative

Alias:

Agl|An|Pc3|Tis21|an-1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Physical Location:

47026985-47030744 on NC_005112.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7832 Symbol (Name): BTG2 (BTG family, member 2)

Ortholog Status:

The human GeneID 7832 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17517326
Method:		Microarray
Tissue:		Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:		The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_017259.1	NP_058955.1	NC_005112.2 range: 47026985..47030744, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005515	protein binding	Molecular Function	IPI
GO:0005515	protein binding	Molecular Function	ISS
GO:0045768	positive regulation of anti-apoptosis	Biological Process	IMP (12360398)
GO:0043434	response to peptide hormone stimulus	Biological Process	IEP (8263025)
GO:0043066	negative regulation of apoptosis	Biological Process	IDA
GO:0030182	neuron differentiation	Biological Process	IDA
GO:0014070	response to organic cyclic substance	Biological Process	IEP (2005087)
GO:0010243	response to organic nitrogen	Biological Process	IEP (2005087)
GO:0010033	response to organic substance	Biological Process	IEP (15084757)
GO:0009952	anterior/posterior pattern formation	Biological Process	ISS
GO:0009952	anterior/posterior pattern formation	Biological Process	IEA
GO:0009612	response to mechanical stimulus	Biological Process	IEP (15519684)
GO:0006479	protein amino acid methylation	Biological Process	ISS
GO:0006479	protein amino acid methylation	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0051602	response to electrical stimulus	Biological Process	IEP (8879470)