ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Nampt

Full Name:

nicotinamide phosphoribosyltransferase

Alias:

Pbef|Pbef1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

6q16

Physical Location:

51129159-51166513 on NC_005105.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 10135 Symbol (Name): NAMPT (nicotinamide phosphoribosyltransferase)

Ortholog Status:

The human GeneID 10135 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17517326
Method:		Microarray
Tissue:		Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:		The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_177928.3	NP_808789.1	NC_005105.2 range: 51129159..51166513

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (12782293)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IDA (12782293)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0047280	nicotinamide phosphoribosyltransferase activity	Molecular Function	IEA
GO:0047280	nicotinamide phosphoribosyltransferase activity	Molecular Function	IDA (4402158)
GO:0042803	protein homodimerization activity	Molecular Function	IDA (16901503)
GO:0016757	transferase activity, transferring glycosyl groups	Molecular Function	IEA
GO:0047280	nicotinamide phosphoribosyltransferase activity	Molecular Function	ISS
GO:0008144	drug binding	Molecular Function	IDA (16901503)
GO:0009435	NAD biosynthetic process	Biological Process	ISS
GO:0014070	response to organic cyclic substance	Biological Process	IEP (17418807)
GO:0007565	female pregnancy	Biological Process	IEP (17641280)
GO:0007049	cell cycle	Biological Process	IPI (12782293)
GO:0009435	NAD biosynthetic process	Biological Process	IEA