ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ICOS

Full Name:

inducible T-cell co-stimulator

Alias:

AILIM|CD278|MGC39850

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

2q33

Physical Location:

204509747-204534544 on NC_000002.10

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 54167 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D2S117

195326948

Region:		195326948-216757195
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012092.2	NP_036224.1	NC_000002.10 range: 204509747..204534544

Gene Ontology (GO) Annotation