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Gene Information
Gene ID:300850
Full Name:glutathione S-transferase, alpha 4
Organism:Rattus norvegicus (Rat)
Genetic Location:8q31
Physical Location:83165168-83183054 on NC_005107.2
Gene Type:protein-coding
Human Ortholog:GeneID: 2941    Symbol (Name): GSTA4 (glutathione S-transferase A4)
Ortholog Status:The human GeneID 2941 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Gsta4
Fold Change:-1.52
Gene Information
Original ID1:Gsta4
Fold Change:-1.78
Gene Information
Original ID1:Gsta4
Fold Change:-1.75
Gene Information
Original ID1:Gsta4
Fold Change:-2.07
Gene Information
Original ID1:Gsta4
Fold Change:-2
Dataset Information
Tissue:Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
XM_217195.3XP_217195.1NC_005107.2 range: 83165168..83183054
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIEA
GO:0004364glutathione transferase activityMolecular FunctionIDA (11018474)
GO:0004364glutathione transferase activityMolecular FunctionIEA
GO:0004364glutathione transferase activityMolecular FunctionISS
GO:0008144drug bindingMolecular FunctionIDA (11018474)
GO:0016740transferase activityMolecular FunctionIEA
GO:0043295glutathione bindingMolecular FunctionIDA (11018474)
GO:0006805xenobiotic metabolic processBiological ProcessIDA (11018474)
GO:0008152metabolic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:300850