ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Mapk8ip3

Full Name:

mitogen-activated protein kinase 8 interacting protein 3

Alias:

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

17 A3.3

Physical Location:

25034498-25073912 on NC_000083.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 23162 Symbol (Name): MAPK8IP3 (mitogen-activated protein kinase 8 interacting protein 3)

Ortholog Status:

The human GeneID 23162 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Mapk8ip3
Fold Change:		0.74
Note:		Significantly regulated in cortical neurons treated with both ethanol and nicotine

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_013931.2	NP_038959.1	NC_000083.5 range: 25034498..25073912, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0042995	cell projection	Cellular Component	IEA
GO:0030425	dendrite	Cellular Component	IDA (16606357)
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	IDA (16606357)
GO:0005794	Golgi apparatus	Cellular Component	IEA
GO:0005790	smooth endoplasmic reticulum	Cellular Component	IDA (16606357)
GO:0005737	cytoplasm	Cellular Component	IEP (11106729)
GO:0005737	cytoplasm	Cellular Component	IDA (10629060\|15767678)
GO:0005625	soluble fraction	Cellular Component	IDA (16606357)
GO:0030673	axolemma	Cellular Component	IDA (16606357)
GO:0019901	protein kinase binding	Molecular Function	IPI (10629060)
GO:0016301	kinase activity	Molecular Function	IEA
GO:0005078	MAP-kinase scaffold activity	Molecular Function	IPI (10629060)
GO:0005515	protein binding	Molecular Function	IPI (11106729)
GO:0019894	kinesin binding	Molecular Function	IPI (10629060)
GO:0030900	forebrain development	Biological Process	IMP (12897243\|15572149)
GO:0016192	vesicle-mediated transport	Biological Process	IDA (11106729)
GO:0008104	protein localization	Biological Process	IMP (15572149)
GO:0007585	respiratory gaseous exchange	Biological Process	IMP (12897243)
GO:0007411	axon guidance	Biological Process	IMP (15572149)
GO:0007257	activation of JNK activity	Biological Process	IDA (15767678)
GO:0007254	JNK cascade	Biological Process	IDA (10629060)
GO:0046328	regulation of JNK cascade	Biological Process	IDA (10629060)