ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

309622

Symbol:

RT1-Bb

Full Name:

RT1 class II, locus Bb

Alias:

MGC94124|RT1.B

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

20p12

Physical Location:

4730558-4736185 on NC_005119.2, complement

Gene Type:

protein-coding

Human Ortholog:

This gene has no human ortholog.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		RT1-Bb
Fold Change:		1.46
Tissue:		Accumbens

Gene Information

Original ID1:		RT1-Bb
Fold Change:		1.39
Tissue:		Amygdala

Dataset Information

Name:		17517326
Method:		Microarray
Tissue:		Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:		The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001004084.1	NP_001004084.1	NC_005119.2 range: 4730558..4736185, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0042613	MHC class II protein complex	Cellular Component	IEA
GO:0005839	proteasome core complex	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	IEA
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA
GO:0005788	endoplasmic reticulum lumen	Cellular Component	ISS
GO:0005788	endoplasmic reticulum lumen	Cellular Component	IEA
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEA
GO:0046982	protein heterodimerization activity	Molecular Function	IEA
GO:0016887	ATPase activity	Molecular Function	IEA
GO:0046980	tapasin binding	Molecular Function	ISS
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	Molecular Function	IEA
GO:0042803	protein homodimerization activity	Molecular Function	IPI
GO:0046978	TAP1 binding	Molecular Function	IPI
GO:0046980	tapasin binding	Molecular Function	IEA
GO:0046979	TAP2 binding	Molecular Function	IPI
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0015198	oligopeptide transporter activity	Molecular Function	IEA
GO:0046982	protein heterodimerization activity	Molecular Function	ISS
GO:0004298	threonine endopeptidase activity	Molecular Function	IEA
GO:0005215	transporter activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0006955	immune response	Biological Process	IEA
GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	Biological Process	IEA
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA
GO:0006810	transport	Biological Process	IEA
GO:0006857	oligopeptide transport	Biological Process	IEA
GO:0006886	intracellular protein transport	Biological Process	IEA
GO:0019882	antigen processing and presentation	Biological Process	IEA
GO:0006952	defense response	Biological Process	IEA
GO:0006886	intracellular protein transport	Biological Process	ISS