ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

HLA-A

Full Name:

major histocompatibility complex, class I, A

Organism:

Homo sapiens (Human)

Chromosome:

6

Genetic Location:

6p21.3

Physical Location:

30018309-30021632 on NC_000006.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

HLA-A

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Information

Original ID	No. of Publications	Phenotype
HLA-A	1	Alcoholism
HLA-A	1	Alcohol-Related Disorders

HuGE Navigator Dataset

Name:		HuGE Navigator
Method:		Literature data mining
Publication:		Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:		HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002116.5	NP_002107.3	NC_000006.10 range: 30018309..30021632

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000139	Golgi membrane	Cellular Component	EXP (15569716)
GO:0031901	early endosome membrane	Cellular Component	EXP (15569716)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005887	integral to plasma membrane	Cellular Component	NAS (1431115\|2437024\|2715640\|6609814\|8188325)
GO:0042612	MHC class I protein complex	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	IPI (12414957\|17353931)
GO:0032393	MHC class I receptor activity	Molecular Function	NAS (1431115\|2437024\|2715640\|6609814\|8188325)
GO:0006955	immune response	Biological Process	IEA
GO:0006955	immune response	Biological Process	NAS (1431115\|2437024\|2715640\|6609814\|8188325)
GO:0019882	antigen processing and presentation	Biological Process	IEA
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000204632

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: