ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

HLA-DRB1

Full Name:

major histocompatibility complex, class II, DR beta 1

Alias:

DRB1|HLA DRB1|HLA-DR1B|HLA-DRB1*

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

6p21.3

Physical Location:

32654526-32665558 on NC_000006.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

HLA-DRB1

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Information

Dataset Information

Name:		15816859
Method:		Microarray
Tissue:		Prefrontal cortex and nucleus accumbens
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:		Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002124.2	NP_002115.2	NC_000006.10 range: 32654526..32665558, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005886	plasma membrane	Cellular Component	EXP (11048639\|11827988\|15489916\|17652306)
GO:0016020	membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	NAS (3129499)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0042613	MHC class II protein complex	Cellular Component	IEA
GO:0032395	MHC class II receptor activity	Molecular Function	NAS (3129499)
GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	Biological Process	IEA
GO:0006955	immune response	Biological Process	IEA
GO:0006955	immune response	Biological Process	NAS (3129499)