ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

HLA-DRB3

Full Name:

major histocompatibility complex, class II, DR beta 3

Alias:

HLA-DR3B|MGC117330

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

6p21.3

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		V00522
Fold Change:		-1.4, -1.5
Note:		Differential Expression on the cDNA array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0042613	MHC class II protein complex	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	TAS (11144299)
GO:0016020	membrane	Cellular Component	IEA
GO:0005887	integral to plasma membrane	Cellular Component	NAS (6414998)
GO:0005886	plasma membrane	Cellular Component	EXP (11048639\|11827988\|15489916\|17652306)
GO:0032395	MHC class II receptor activity	Molecular Function	NAS (6414998)
GO:0032395	MHC class II receptor activity	Molecular Function	TAS (11144299)
GO:0006955	immune response	Biological Process	TAS (10609818)
GO:0007165	signal transduction	Biological Process	NAS (8775462)
GO:0006955	immune response	Biological Process	IEA
GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	Biological Process	IEA