ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Nrcam

Full Name:

neuron-glia-CAM-related cell adhesion molecule

Alias:

Bravo|C030017F07Rik|C130076O07Rik|mKIAA0343

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

12 B3

Physical Location:

45429970-45699827 on NC_000078.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4897 Symbol (Name): NRCAM (neuronal cell adhesion molecule)

Ortholog Status:

The human GeneID 4897 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Nrcam
Fold Change:		1.22
Note:		Significantly regulated in cortical neurons treated with both ethanol and nicotine

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_176930.3	NP_795904.2	NC_000078.5 range: 45429970..45699827

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0045202	synapse	Cellular Component	IDA (16882004)
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0005886	plasma membrane	Cellular Component	IDA (16882004)
GO:0030424	axon	Cellular Component	IDA (14602817)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	IPI (16882004)
GO:0007417	central nervous system development	Biological Process	IDA (12182881)
GO:0007411	axon guidance	Biological Process	IDA (12182881)
GO:0016337	cell-cell adhesion	Biological Process	IDA (12182881)
GO:0019227	action potential propagation	Biological Process	IMP (14602817)
GO:0007155	cell adhesion	Biological Process	IEA
GO:0008104	protein localization	Biological Process	IDA (16882004)