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Gene Information
Gene ID:319504
Full Name:neuron-glia-CAM-related cell adhesion molecule
Organism:Mus musculus (Mouse)
Genetic Location:12 B3
Physical Location:45429970-45699827 on NC_000078.5
Gene Type:protein-coding
Human Ortholog:GeneID: 4897    Symbol (Name): NRCAM (neuronal cell adhesion molecule)
Ortholog Status:The human GeneID 4897 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Nrcam
Fold Change:1.22
Note:Significantly regulated in cortical neurons treated with both ethanol and nicotine
Dataset Information
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_176930.3NP_795904.2NC_000078.5 range: 45429970..45699827
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0045202synapseCellular ComponentIDA (16882004)
GO:0005615extracellular spaceCellular ComponentRCA (12466851)
GO:0005886plasma membraneCellular ComponentIDA (16882004)
GO:0030424axonCellular ComponentIDA (14602817)
GO:0016021integral to membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0005515protein bindingMolecular FunctionIPI (16882004)
GO:0007417central nervous system developmentBiological ProcessIDA (12182881)
GO:0007411axon guidanceBiological ProcessIDA (12182881)
GO:0016337cell-cell adhesionBiological ProcessIDA (12182881)
GO:0019227action potential propagationBiological ProcessIMP (14602817)
GO:0007155cell adhesionBiological ProcessIEA
GO:0008104protein localizationBiological ProcessIDA (16882004)
Other Database Cross Links
NCBI Entrez Gene:319504