ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

APEX1

Full Name:

APEX nuclease (multifunctional DNA repair enzyme) 1

Alias:

APE|APE-1|APE1|APEN|APEX|APX|HAP1|REF-1|REF1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

14q11.2-q12

Physical Location:

19993129-19995765 on NC_000014.7

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

APEX1

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (9119221)
GO:0005654	nucleoplasm	Cellular Component	EXP (9207062\|10559261\|11250913)
GO:0005783	endoplasmic reticulum	Cellular Component	TAS (12524539)
GO:0005840	ribosome	Cellular Component	TAS (12524539)
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IDA (12524539)
GO:0005622	intracellular	Cellular Component	IEA
GO:0008408	3'-5' exonuclease activity	Molecular Function	TAS (11286553)
GO:0016491	oxidoreductase activity	Molecular Function	IDA (9119221)
GO:0016829	lyase activity	Molecular Function	IEA
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (12524539)
GO:0004844	uracil DNA N-glycosylase activity	Molecular Function	TAS (10805771)
GO:0004528	phosphodiesterase I activity	Molecular Function	TAS (9119221)
GO:0004523	ribonuclease H activity	Molecular Function	TAS (11286553)
GO:0004520	endodeoxyribonuclease activity	Molecular Function	TAS (1722334)
GO:0003677	DNA binding	Molecular Function	IDA (11286553)
GO:0003713	transcription coactivator activity	Molecular Function	IDA (9119221)
GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	Molecular Function	TAS (9119221)
GO:0003714	transcription corepressor activity	Molecular Function	TAS (7961715)
GO:0006366	transcription from RNA polymerase II promoter	Biological Process	TAS (1380454)
GO:0006284	base-excision repair	Biological Process	TAS (11286553)
GO:0051101	regulation of DNA binding	Biological Process	IDA (9119221)