ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

HSP90AB1

Full Name:

heat shock protein 90kDa alpha (cytosolic), class B member 1

Alias:

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

6p12

Physical Location:

44322826-44329591 on NC_000006.10

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 15516 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		J04988
Fold Change:		1.4, 1.5
Note:		Differential expression on the oligonucleotide array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007355.2	NP_031381.2	NC_000006.10 range: 44322826..44329591

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0042470	melanosome	Cellular Component	IEA
GO:0005575	cellular_component	Cellular Component	ND
GO:0005737	cytoplasm	Cellular Component	NAS
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0030911	TPR domain binding	Molecular Function	ISS
GO:0030235	nitric-oxide synthase regulator activity	Molecular Function	ISS
GO:0051082	unfolded protein binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0006457	protein folding	Biological Process	IEA
GO:0045429	positive regulation of nitric oxide biosynthetic process	Biological Process	ISS
GO:0006986	response to unfolded protein	Biological Process	NAS (2768249)