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Gene Information
Gene ID:3326
Symbol:HSP90AB1
Full Name:heat shock protein 90kDa alpha (cytosolic), class B member 1
Alias:D6S182|FLJ26984|HSP90-BETA|HSP90B|HSPC2|HSPCB
Organism:Homo sapiens (Human)
Chromosome:6
Genetic Location:6p12
Physical Location:44322826-44329591 on NC_000006.10
Gene Type:protein-coding
Orthologs:This gene has Mouse: 15516 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:J04988
Fold Change:1.4, 1.5
Note:Differential expression on the oligonucleotide array (two fold changes are from two case groups)
Dataset Information
Name:11141048
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_007355.2NP_031381.2NC_000006.10 range: 44322826..44329591
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0042470melanosomeCellular ComponentIEA
GO:0005575cellular_componentCellular ComponentND
GO:0005737cytoplasmCellular ComponentNAS
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0030911TPR domain bindingMolecular FunctionISS
GO:0030235nitric-oxide synthase regulator activityMolecular FunctionISS
GO:0051082unfolded protein bindingMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0006457protein foldingBiological ProcessIEA
GO:0045429positive regulation of nitric oxide biosynthetic processBiological ProcessISS
GO:0006986response to unfolded proteinBiological ProcessNAS (2768249)
Other Database Cross Links
NCBI Entrez Gene:3326
HGNC:5258
Ensembl:ENSG00000096384
MIM:140572
HPRD:06763
HuGE Navigator:3326
dbSNP:HSP90AB1
GeneCard:HSP90AB1
AceView:HSP90AB1