ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

HSPD1

Full Name:

heat shock 60kDa protein 1 (chaperonin)

Alias:

CPN60|GROEL|HSP60|HSP65|HuCHA60|SPG13

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

2q33.1

Physical Location:

198059552-198073242 on NC_000002.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		M22382
Fold Change:		-1.8, -1.8
Note:		Differential expression on the oligonucleotide array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D2S117

195326948

Region:		195326948-216757195
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	TAS (16130169)
GO:0005739	mitochondrion	Cellular Component	TAS (16130169)
GO:0005759	mitochondrial matrix	Cellular Component	IEA
GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex	Cellular Component	IDA (11445587)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0051082	unfolded protein binding	Molecular Function	TAS (16130169)
GO:0051082	unfolded protein binding	Molecular Function	IEA
GO:0051087	chaperone binding	Molecular Function	IPI (10205158)
GO:0005524	ATP binding	Molecular Function	NAS
GO:0005524	ATP binding	Molecular Function	IEA
GO:0006457	protein folding	Biological Process	NAS (2568584)
GO:0006986	response to unfolded protein	Biological Process	NAS (2568584)
GO:0006457	protein folding	Biological Process	IEA
GO:0030150	protein import into mitochondrial matrix	Biological Process	NAS
GO:0042981	regulation of apoptosis	Biological Process	TAS (16130169)
GO:0006950	response to stress	Biological Process	IEA