ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

IFI16

Full Name:

interferon, gamma-inducible protein 16

Alias:

IFNGIP1|MGC9466|PYHIN2

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

1q22

Physical Location:

157246305-157291568 on NC_000001.9

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 15951 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		S75433
Fold Change:		-1.6, -1.4
Note:		Differential Expression on the cDNA array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_005531.2	NP_005522.2	NC_000001.9 range: 157246305..157291568

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005654	nucleoplasm	Cellular Component	IDA (14654789)
GO:0005730	nucleolus	Cellular Component	IDA (14654789)
GO:0005634	nucleus	Cellular Component	IDA (7536752)
GO:0003677	DNA binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IDA (14654789)
GO:0003690	double-stranded DNA binding	Molecular Function	IDA (7536752)
GO:0016564	transcription repressor activity	Molecular Function	IDA (9642285)
GO:0030224	monocyte differentiation	Biological Process	IDA (9766636)
GO:0030099	myeloid cell differentiation	Biological Process	NAS (7536752)
GO:0009615	response to virus	Biological Process	NAS
GO:0008283	cell proliferation	Biological Process	NAS (9766636)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	NAS
GO:0006350	transcription	Biological Process	IEA
GO:0042771	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	Biological Process	IDA (14654789)