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Gene Information
Gene ID:3479
Symbol:IGF1
Full Name:insulin-like growth factor 1 (somatomedin C)
Alias:IGFI
Organism:Homo sapiens (Human)
Chromosome:12
Genetic Location:12q22-q23
Physical Location:101313805-101398453 on NC_000012.10, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:IGF1
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Linkage Dataset
MarkerLODP valueLocation (bp)
D12S346  98052454
Region:98052454-102788867
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Name:15211641
Method:Linkage
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000618.3NP_000609.1NC_000012.10 range: 101313805..101398453, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0031093platelet alpha granule lumenCellular ComponentEXP (2752154)
GO:0005576extracellular regionCellular ComponentNAS (14718574)
GO:0005576extracellular regionCellular ComponentEXP (2752154)
GO:0005576extracellular regionCellular ComponentIEA
GO:0018445prothoracicotrophic hormone activityMolecular FunctionIEA
GO:0008083growth factor activityMolecular FunctionIEA
GO:0005179hormone activityMolecular FunctionTAS (9681507)
GO:0005179hormone activityMolecular FunctionIEA
GO:0005159insulin-like growth factor receptor bindingMolecular FunctionTAS (10749889)
GO:0030166proteoglycan biosynthetic processBiological ProcessIDA (12746903)
GO:0009441glycolate metabolic processBiological ProcessTAS (10448861)
GO:0008284positive regulation of cell proliferationBiological ProcessTAS (10749889)
GO:0008284positive regulation of cell proliferationBiological ProcessIDA (12746903)
GO:0001501skeletal developmentBiological ProcessTAS (10448861)
GO:0007605sensory perception of soundBiological ProcessIEA
GO:0007517muscle developmentBiological ProcessTAS (10448861)
GO:0007265Ras protein signal transductionBiological ProcessTAS (10848592)
GO:0007165signal transductionBiological ProcessTAS (10448861)
GO:0006928cell motilityBiological ProcessTAS (10766744)
GO:0006260DNA replicationBiological ProcessTAS (10766744)
GO:0033143regulation of steroid hormone receptor signaling pathwayBiological ProcessIDA (10459853)
Other Database Cross Links
NCBI Entrez Gene:3479
HGNC:5464
Ensembl:ENSG00000017427
MIM:147440
HPRD:00936
HuGE Navigator:3479
dbSNP:IGF1
GeneCard:IGF1
AceView:IGF1