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Gene Information
Gene ID:348
Symbol:APOE
Full Name:apolipoprotein E
Alias:AD2|LPG|MGC1571|apoprotein
Organism:Homo sapiens (Human)
Chromosome:19
Genetic Location:19q13.2
Physical Location:50100878-50104489 on NC_000019.8
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:APOE
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Information
Original IDNo. of PublicationsPhenotype
APOE2Alcohol Amnestic Disorder
APOE4Alcohol-Induced Disorders
APOE3Alcohol-Induced Disorders Nervous System
APOE13Alcoholism
APOE11Alcohol-Related Disorders
APOE1Alcohol Withdrawal Seizures
HuGE Navigator Dataset
Name:HuGE Navigator
Method:Literature data mining
Publication:Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000041.2NP_000032.1NC_000019.8 range: 50100878..50104489
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005576extracellular regionCellular ComponentIEA
GO:0030425dendriteCellular ComponentNAS (8083695)
GO:0005886plasma membraneCellular ComponentEXP (8300609)
GO:0005737cytoplasmCellular ComponentTAS (9622609)
GO:0005576extracellular regionCellular ComponentEXP (4345202|8300609)
GO:0043025cell somaCellular ComponentNAS (8083695)
GO:0042627chylomicronCellular ComponentIEA
GO:0016209antioxidant activityMolecular FunctionIDA (9685360)
GO:0008289lipid bindingMolecular FunctionIEA
GO:0042803protein homodimerization activityMolecular FunctionIDA (8245722)
GO:0008201heparin bindingMolecular FunctionIEA
GO:0046911metal chelating activityMolecular FunctionIDA (9685360)
GO:0046982protein heterodimerization activityMolecular FunctionIPI (8245722)
GO:0048156tau protein bindingMolecular FunctionIPI (7566652)
GO:0050749apolipoprotein E receptor bindingMolecular FunctionIDA (1384047)
GO:0001540beta-amyloid bindingMolecular FunctionIDA (11305869)
GO:0050749apolipoprotein E receptor bindingMolecular FunctionIPI (12950167)
GO:0005319lipid transporter activityMolecular FunctionIEA
GO:0005543phospholipid bindingMolecular FunctionIDA (4066713)
GO:0048168regulation of neuronal synaptic plasticityBiological ProcessTAS (9622609)
GO:0042157lipoprotein metabolic processBiological ProcessIEA
GO:0042632cholesterol homeostasisBiological ProcessIDA (9649566)
GO:0051262protein tetramerizationBiological ProcessIDA (4066713)
GO:0043407negative regulation of MAP kinase activityBiological ProcessIDA (9685360)
GO:0051044positive regulation of membrane protein ectodomain proteolysisBiological ProcessIDA (15950758)
GO:0043537negative regulation of blood vessel endothelial cell migrationBiological ProcessIDA (9685360)
GO:0051000positive regulation of nitric-oxide synthase activityBiological ProcessIDA (8995232)
GO:0043691reverse cholesterol transportBiological ProcessIDA (8127890)
GO:0046907intracellular transportBiological ProcessTAS (9622609)
GO:0050728negative regulation of inflammatory responseBiological ProcessIC (8995232)
GO:0033700phospholipid effluxBiological ProcessIDA (11162594)
GO:0033344cholesterol effluxBiological ProcessIDA (11162594|16443932)
GO:0032801receptor catabolic processBiological ProcessIDA (15950758)
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessIDA (16443932)
GO:0007010cytoskeleton organization and biogenesisBiological ProcessTAS (9622609)
GO:0006917induction of apoptosisBiological ProcessIDA (12753088)
GO:0006916anti-apoptosisBiological ProcessIDA (9685360)
GO:0006869lipid transportBiological ProcessIEA
GO:0006641triacylglycerol metabolic processBiological ProcessIMP (3771793)
GO:0006641triacylglycerol metabolic processBiological ProcessIDA (9649566)
GO:0000302response to reactive oxygen speciesBiological ProcessNAS (11743999)
GO:0007263nitric oxide mediated signal transductionBiological ProcessIDA (8995232)
GO:0007271synaptic transmission, cholinergicBiological ProcessTAS (9622609)
GO:0032488Cdc42 protein signal transductionBiological ProcessIDA (16443932)
GO:0030828positive regulation of cGMP biosynthetic processBiological ProcessIDA (8995232)
GO:0030516regulation of axon extensionBiological ProcessTAS (9622609)
GO:0008203cholesterol metabolic processBiological ProcessIDA (9649566)
GO:0019934cGMP-mediated signalingBiological ProcessIDA (8995232)
GO:0010544negative regulation of platelet activationBiological ProcessIDA (8995232)
GO:0008203cholesterol metabolic processBiological ProcessIMP (3771793)
GO:0007611learning and/or memoryBiological ProcessTAS (9622609)
GO:0001937negative regulation of endothelial cell proliferationBiological ProcessIDA (9685360)
Other Database Cross Links
NCBI Entrez Gene:348
HGNC:613
Ensembl:ENSG00000130203
MIM:107741
HPRD:00135
HuGE Navigator:348
dbSNP:APOE
GeneCard:APOE
AceView:APOE