ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

IKBKB

Full Name:

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

Alias:

FLJ40509|IKK-beta|IKK2|IKKB|MGC131801|NFKBIKB

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

8p11.2

Physical Location:

42247985-42309121 on NC_000008.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		15816859
Method:		Microarray
Tissue:		Prefrontal cortex and nucleus accumbens
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:		Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001556.1	NP_001547.1	NC_000008.9 range: 42247985..42309121

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	NAS
GO:0005829	cytosol	Cellular Component	EXP (9744859\|10723127)
GO:0016563	transcription activator activity	Molecular Function	NAS (9346484\|9346485\|9813230)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0042802	identical protein binding	Molecular Function	IPI (16319058)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	NAS
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004713	protein-tyrosine kinase activity	Molecular Function	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0008384	IkappaB kinase activity	Molecular Function	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	NAS (9346484)
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0006464	protein modification process	Biological Process	IEA
GO:0051092	activation of NF-kappaB transcription factor	Biological Process	IDA (15790681)