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Gene Information
Gene ID:3553
Symbol:IL1B
Full Name:interleukin 1, beta
Alias:IL-1|IL1-BETA|IL1F2
Organism:Homo sapiens (Human)
Chromosome:2
Genetic Location:2q14
Physical Location:113303807-113310826 on NC_000002.10, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:IL1B
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Information
Original IDNo. of PublicationsPhenotype
IL1B1Alcohol-Induced Disorders
IL1B2Alcoholism
IL1B2Alcohol-Related Disorders
HuGE Navigator Dataset
Name:HuGE Navigator
Method:Literature data mining
Publication:Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000576.2NP_000567.1NC_000002.10 range: 113303807..113310826, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005615extracellular spaceCellular ComponentTAS (3493774)
GO:0005576extracellular regionCellular ComponentNAS (1919436)
GO:0005515protein bindingMolecular FunctionIPI (9062193)
GO:0004871signal transducer activityMolecular FunctionTAS (10786823)
GO:0005149interleukin-1 receptor bindingMolecular FunctionNAS (1919436)
GO:0007267cell-cell signalingBiological ProcessTAS (2989698)
GO:0008285negative regulation of cell proliferationBiological ProcessTAS (3493774)
GO:0000187activation of MAPK activityBiological ProcessIDA (10748004)
GO:0019221cytokine and chemokine mediated signaling pathwayBiological ProcessIDA (10748004)
GO:0043122regulation of I-kappaB kinase/NF-kappaB cascadeBiological ProcessIDA (10748004)
GO:0007165signal transductionBiological ProcessTAS (9218611|10786823)
GO:0006955immune responseBiological ProcessIEA
GO:0006954inflammatory responseBiological ProcessNAS (1919436)
GO:0006916anti-apoptosisBiological ProcessIDA (10748004)
GO:0006915apoptosisBiological ProcessTAS (9218611)
GO:0001934positive regulation of protein amino acid phosphorylationBiological ProcessIDA (10748004)
GO:0001660feverBiological ProcessIEA
GO:0051091positive regulation of transcription factor activityBiological ProcessIDA (10748004)
Other Database Cross Links
NCBI Entrez Gene:3553
HGNC:5992
Ensembl:ENSG00000125538
MIM:147720
HPRD:00985
HuGE Navigator:3553
dbSNP:IL1B
GeneCard:IL1B
AceView:IL1B