| Gene Information |
| Gene ID: | | 3554 |
| Symbol: | | IL1R1 |
| Full Name: | | interleukin 1 receptor, type I |
| Alias: | | CD121A|D2S1473|IL-1R-alpha|IL1R|IL1RA|P80 |
| Organism: | | Homo sapiens (Human) |
| Chromosome: | | 2 |
| Genetic Location: | | 2q12 |
| Physical Location: | | 102136833-102162765 on NC_000002.10 |
| Gene Type: | | protein-coding |
| Orthologs: | | This gene has no orthologs in other dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | | Dataset Information | | Name: | | Literature Search | | Method: | | Literature search | | Summary: | | We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive. |
| | Gene Information | | Original ID1: | | W03241 | | Fold Change: | | 1.5 | | P Value: | | 0.05 | | Tissue: | | Nucleus accumbens |
| | Dataset Information | | Name: | | 15816859 | | Method: | | Microarray | | Tissue: | | Prefrontal cortex and nucleus accumbens | | Phenotype: | | Alcohol dependence (AD)/Alcohol abuse/Alcoholism | | Publication: | | Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed | | Summary: | | Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test. |
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| Gene Information | | Original ID | No. of Publications | Phenotype | |
| IL1R1 | 1 | Alcoholism | | IL1R1 | 1 | Alcohol-Related Disorders |
| | HuGE Navigator Dataset | | Name: | | HuGE Navigator | | Method: | | Literature data mining | | Publication: | | Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008]. | | Summary: | | HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005887 | integral to plasma membrane | Cellular Component | TAS (2530587) | |
| GO:0016020 | membrane | Cellular Component | IEA | |
| GO:0004888 | transmembrane receptor activity | Molecular Function | TAS (2530587) | |
| GO:0004909 | interleukin-1, Type I, activating receptor activity | Molecular Function | TAS (9120302) | |
| GO:0005515 | protein binding | Molecular Function | IPI (9062193|9062194|12721283|16286467) | |
| GO:0006954 | inflammatory response | Biological Process | NR | |
| GO:0007166 | cell surface receptor linked signal transduction | Biological Process | TAS (1833184) | |
| GO:0045087 | innate immune response | Biological Process | IEA | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 3554 |
| HGNC: | | 5993 |
| Ensembl: | | ENSG00000115594 |
| MIM: | | 147810 |
| HPRD: | | 00994 |
| HuGE Navigator: | | 3554 |
| dbSNP: | | IL1R1 |
| GeneCard: | | IL1R1 |
| AceView: | | IL1R1 |
