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Gene Information
Gene ID:3569
Symbol:IL6
Full Name:interleukin 6 (interferon, beta 2)
Alias:BSF2|HGF|HSF|IFNB2|IL-6
Organism:Homo sapiens (Human)
Chromosome:7
Genetic Location:7p21
Physical Location:22733342-22738144 on NC_000007.12
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:IL6
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Information
Original IDNo. of PublicationsPhenotype
IL61Alcohol-Induced Disorders
IL61Alcohol-Related Disorders
HuGE Navigator Dataset
Name:HuGE Navigator
Method:Literature data mining
Publication:Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000600.2NP_000591.1NC_000007.12 range: 22733342..22738144
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005576extracellular regionCellular ComponentNAS (1883960|14718574)
GO:0005615extracellular spaceCellular ComponentTAS (10925276)
GO:0005125cytokine activityMolecular FunctionIEA
GO:0005138interleukin-6 receptor bindingMolecular FunctionNAS (1883960)
GO:0001781neutrophil apoptosisBiological ProcessIDA (7595060)
GO:0043066negative regulation of apoptosisBiological ProcessIDA (7595060)
GO:0043410positive regulation of MAPKKK cascadeBiological ProcessIDA (7508917)
GO:0045079negative regulation of chemokine biosynthetic processBiological ProcessISS
GO:0045727positive regulation of translationBiological ProcessIDA (16732314)
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessIDA (7508917)
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationBiological ProcessIDA (7508917)
GO:0033138positive regulation of peptidyl-serine phosphorylationBiological ProcessIDA (7508917)
GO:0008285negative regulation of cell proliferationBiological ProcessTAS (3023045)
GO:0008284positive regulation of cell proliferationBiological ProcessTAS (2829354)
GO:0007267cell-cell signalingBiological ProcessNAS (1883960)
GO:0007166cell surface receptor linked signal transductionBiological ProcessTAS (10925276)
GO:0006959humoral immune responseBiological ProcessTAS (2829354)
GO:0006954inflammatory responseBiological ProcessIDA (10443688)
GO:0006953acute-phase responseBiological ProcessIEA
GO:0051384response to glucocorticoid stimulusBiological ProcessIDA (10443688)
Other Database Cross Links
NCBI Entrez Gene:3569
HGNC:6018
Ensembl:ENSG00000136244
MIM:147620
HPRD:00970
HuGE Navigator:3569
dbSNP:IL6
GeneCard:IL6
AceView:IL6