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Gene Information
Gene ID:3576
Symbol:IL8
Full Name:interleukin 8
Alias:3-10C|AMCF-I|CXCL8|GCP-1|GCP1|K60|LECT|LUCT|LYNAP|MDNCF|MONAP|NAF|NAP-1|NAP1|SCYB8|TSG-1|b-ENAP
Organism:Homo sapiens (Human)
Chromosome:4
Genetic Location:4q13-q21
Physical Location:74825138-74828296 on NC_000004.10
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:IL8
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Information
Original IDNo. of PublicationsPhenotype
IL81Alcohol-Induced Disorders
IL81Alcohol-Related Disorders
HuGE Navigator Dataset
Name:HuGE Navigator
Method:Literature data mining
Publication:Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000584.2NP_000575.1NC_000004.10 range: 74825138..74828296
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005576extracellular regionCellular ComponentIEA
GO:0005615extracellular spaceCellular ComponentTAS (10823949)
GO:0008009chemokine activityMolecular FunctionTAS (10881932)
GO:0005153interleukin-8 receptor bindingMolecular FunctionIPI (1840701)
GO:0005515protein bindingMolecular FunctionIPI (10880251)
GO:0008285negative regulation of cell proliferationBiological ProcessTAS (9551928)
GO:0019722calcium-mediated signalingBiological ProcessTAS (11877327)
GO:0030155regulation of cell adhesionBiological ProcessIDA (2007144)
GO:0030593neutrophil chemotaxisBiological ProcessIGI (11564821)
GO:0042119neutrophil activationBiological ProcessTAS (11483765)
GO:0045091regulation of retroviral genome replicationBiological ProcessIDA (11483765)
GO:0001525angiogenesisBiological ProcessTAS (11483765)
GO:0007267cell-cell signalingBiological ProcessIC (10881932)
GO:0007242intracellular signaling cascadeBiological ProcessTAS (10734056)
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessTAS (8381837)
GO:0007050cell cycle arrestBiological ProcessIDA (11564821)
GO:0006955immune responseBiological ProcessIEA
GO:0006954inflammatory responseBiological ProcessTAS (11483765)
GO:0006935chemotaxisBiological ProcessTAS (10620615)
GO:0006928cell motilityBiological ProcessTAS (10820279)
GO:0050930induction of positive chemotaxisBiological ProcessIGI (11564821)
Other Database Cross Links
NCBI Entrez Gene:3576
HGNC:6025
Ensembl:ENSG00000169429
MIM:146930
HPRD:00909
HuGE Navigator:3576
dbSNP:IL8
GeneCard:IL8
AceView:IL8