ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

IL8

Full Name:

interleukin 8

Alias:

3-10C|AMCF-I|CXCL8|GCP-1|GCP1|K60|LECT|LUCT|LYNAP|MDNCF|MONAP|NAF|NAP-1|NAP1|SCYB8|TSG-1|b-ENAP

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

4q13-q21

Physical Location:

74825138-74828296 on NC_000004.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

IL8

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Information

HuGE Navigator Dataset

Name:		HuGE Navigator
Method:		Literature data mining
Publication:		Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:		HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000584.2	NP_000575.1	NC_000004.10 range: 74825138..74828296

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	TAS (10823949)
GO:0008009	chemokine activity	Molecular Function	TAS (10881932)
GO:0005153	interleukin-8 receptor binding	Molecular Function	IPI (1840701)
GO:0005515	protein binding	Molecular Function	IPI (10880251)
GO:0008285	negative regulation of cell proliferation	Biological Process	TAS (9551928)
GO:0019722	calcium-mediated signaling	Biological Process	TAS (11877327)
GO:0030155	regulation of cell adhesion	Biological Process	IDA (2007144)
GO:0030593	neutrophil chemotaxis	Biological Process	IGI (11564821)
GO:0042119	neutrophil activation	Biological Process	TAS (11483765)
GO:0045091	regulation of retroviral genome replication	Biological Process	IDA (11483765)
GO:0001525	angiogenesis	Biological Process	TAS (11483765)
GO:0007267	cell-cell signaling	Biological Process	IC (10881932)
GO:0007242	intracellular signaling cascade	Biological Process	TAS (10734056)
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	TAS (8381837)
GO:0007050	cell cycle arrest	Biological Process	IDA (11564821)
GO:0006955	immune response	Biological Process	IEA
GO:0006954	inflammatory response	Biological Process	TAS (11483765)
GO:0006935	chemotaxis	Biological Process	TAS (10620615)
GO:0006928	cell motility	Biological Process	TAS (10820279)
GO:0050930	induction of positive chemotaxis	Biological Process	IGI (11564821)