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Gene Information
Gene ID:358
Symbol:AQP1
Full Name:aquaporin 1 (Colton blood group)
Alias:AQP-CHIP|CHIP28|CO|MGC26324
Organism:Homo sapiens (Human)
Chromosome:7
Genetic Location:7p14
Physical Location:30917992-30931655 on NC_000007.12
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:U41517
Fold Change:-1.8, -2.2
Note:Differential Expression on the cDNA array (two fold changes are from two case groups)
Dataset Information
Name:11141048
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.
Gene Information
Original ID1:AQP1
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_198098.1NP_932766.1NC_000007.12 range: 30917992..30931655
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005887integral to plasma membraneCellular ComponentTAS (1722319)
GO:0016020membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0005215transporter activityMolecular FunctionIEA
GO:0005372water transporter activityMolecular FunctionTAS (7521540)
GO:0006810transportBiological ProcessIEA
GO:0006833water transportBiological ProcessTAS (7521540)
GO:0007588excretionBiological ProcessTAS (1722319)
Other Database Cross Links
NCBI Entrez Gene:358
HGNC:633
Ensembl:ENSG00000106125
MIM:107776
HPRD:00140
HuGE Navigator:358
dbSNP:AQP1
GeneCard:AQP1
AceView:AQP1