ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

IMPA2

Full Name:

inositol(myo)-1(or 4)-monophosphatase 2

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

18p11.2

Physical Location:

11971454-12020875 on NC_000018.8

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 282636 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D18S53

11482730

Region:		9482730-13482730
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_014214.1	NP_055029.1	NC_000018.8 range: 11971454..12020875

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0004437	inositol or phosphatidylinositol phosphatase activity	Molecular Function	IEA
GO:0008934	inositol-1(or 4)-monophosphatase activity	Molecular Function	TAS (9322233)
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0006796	phosphate metabolic process	Biological Process	TAS (9322233)
GO:0007165	signal transduction	Biological Process	TAS (9322233)