ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Irak2

Full Name:

interleukin-1 receptor-associated kinase 2

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

4q42

Physical Location:

149543028-149599462 on NC_005103.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3656 Symbol (Name): IRAK2 (interleukin-1 receptor-associated kinase 2)

Ortholog Status:

The human GeneID 3656 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17517326
Method:		Microarray
Tissue:		Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:		The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001025422.1	NP_001020593.1	NC_005103.2 range: 149543028..149599462

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0009986	cell surface	Cellular Component	ISS
GO:0042802	identical protein binding	Molecular Function	ISS
GO:0004672	protein kinase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0007165	signal transduction	Biological Process	IEA
GO:0007250	activation of NF-kappaB-inducing kinase activity	Biological Process	ISS
GO:0031663	lipopolysaccharide-mediated signaling pathway	Biological Process	ISS
GO:0043433	negative regulation of transcription factor activity	Biological Process	ISS
GO:0046777	protein amino acid autophosphorylation	Biological Process	ISS
GO:0051092	activation of NF-kappaB transcription factor	Biological Process	ISS