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Gene Information
Gene ID:3630
Symbol:INS
Full Name:insulin
Organism:Homo sapiens (Human)
Chromosome:11
Genetic Location:11p15.5
Physical Location:2137584-2139014 on NC_000011.8, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:INS
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Information
Original IDNo. of PublicationsPhenotype
INS1Alcoholism
HuGE Navigator Dataset
Name:HuGE Navigator
Method:Literature data mining
Publication:Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000207.2NP_000198.1NC_000011.8 range: 2137584..2139014, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005576extracellular regionCellular ComponentIC (7556975)
GO:0005158insulin receptor bindingMolecular FunctionIDA (7556975)
GO:0005179hormone activityMolecular FunctionNAS (14986111)
GO:0005515protein bindingMolecular FunctionIPI (9773776)
GO:0005520insulin-like growth factor bindingMolecular FunctionIPI (9388210)
GO:0045429positive regulation of nitric oxide biosynthetic processBiological ProcessNAS (14615391)
GO:0045908negative regulation of vasodilationBiological ProcessNAS (12946932)
GO:0045909positive regulation of vasodilationBiological ProcessNAS (14744991)
GO:0046631alpha-beta T cell activationBiological ProcessIDA (10604997)
GO:0050708regulation of protein secretionBiological ProcessIDA (15591776)
GO:0050715positive regulation of cytokine secretionBiological ProcessIDA (15473891)
GO:0042177negative regulation of protein catabolic processBiological ProcessIDA (15185208)
GO:0015758glucose transportBiological ProcessIDA (14615391|15792832)
GO:0008219cell deathBiological ProcessNAS (15194403)
GO:0007267cell-cell signalingBiological ProcessIC (7556975)
GO:0007166cell surface receptor linked signal transductionBiological ProcessTAS (381941)
GO:0006953acute-phase responseBiological ProcessNAS (14739855)
GO:0006091generation of precursor metabolites and energyBiological ProcessTAS (381941)
GO:0006006glucose metabolic processBiological ProcessTAS (381941)
GO:0005975carbohydrate metabolic processBiological ProcessIEA
GO:0051000positive regulation of nitric-oxide synthase activityBiological ProcessNAS (12135947)
Other Database Cross Links
NCBI Entrez Gene:3630
HGNC:6081
Ensembl:ENSG00000129965
MIM:176730
HPRD:01455
HuGE Navigator:3630
dbSNP:INS
GeneCard:INS
AceView:INS