ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

INPP5A

Full Name:

inositol polyphosphate-5-phosphatase, 40kDa

Alias:

5PTASE|DKFZp434A1721|MGC116947|MGC116949

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

10q26.3

Physical Location:

134201342-134446973 on NC_000010.9

Gene Type:

protein-coding

Orthologs:

This gene has Worm: 180871 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D10S1651

132582544

Region:		132582544-134299794
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_005539.3	NP_005530.3	NC_000010.9 range: 134201342..134446973

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005575	cellular_component	Cellular Component	ND
GO:0016020	membrane	Cellular Component	NAS (8006039)
GO:0004437	inositol or phosphatidylinositol phosphatase activity	Molecular Function	IEA
GO:0004445	inositol-polyphosphate 5-phosphatase activity	Molecular Function	NAS (8006039)
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0007154	cell communication	Biological Process	NAS
GO:0008150	biological_process	Biological Process	ND