ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

IRS1

Full Name:

insulin receptor substrate 1

Alias:

HIRS-1

Organism:

Homo sapiens (Human)

Chromosome:

2

Genetic Location:

2q36

Physical Location:

227308181-227372718 on NC_000002.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

IRS1

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_005544.2	NP_005535.1	NC_000002.10 range: 227308181..227372718, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005792	microsome	Cellular Component	ISS
GO:0005886	plasma membrane	Cellular Component	EXP (12167717)
GO:0005634	nucleus	Cellular Component	ISS
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0043548	phosphoinositide 3-kinase binding	Molecular Function	ISS
GO:0043548	phosphoinositide 3-kinase binding	Molecular Function	IPI (16043515)
GO:0042169	SH2 domain binding	Molecular Function	ISS
GO:0004871	signal transducer activity	Molecular Function	TAS (1311924\|8513971)
GO:0005515	protein binding	Molecular Function	IPI (8388384\|9295312\|11018022)
GO:0005159	insulin-like growth factor receptor binding	Molecular Function	IPI (7541045)
GO:0005158	insulin receptor binding	Molecular Function	IPI (7537849\|7559478)
GO:0005069	transmembrane receptor protein tyrosine kinase docking protein activity	Molecular Function	TAS (1648180)
GO:0007165	signal transduction	Biological Process	TAS (1311924)
GO:0008286	insulin receptor signaling pathway	Biological Process	IPI (7537849\|7559478)
GO:0048009	insulin-like growth factor receptor signaling pathway	Biological Process	IPI (7541045)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000169047

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: