ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

KCNJ10

Full Name:

potassium inwardly-rectifying channel, subfamily J, member 10

Alias:

BIRK-10|KCNJ13-PEN|KIR1.2|KIR4.1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

1q22-q23

Physical Location:

158274656-158306584 on NC_000001.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 16513 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		U52155
Fold Change:		-1.5, -1.9
Note:		Differential Expression on the cDNA array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002241.3	NP_002232.2	NC_000001.9 range: 158274656..158306584, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005887	integral to plasma membrane	Cellular Component	TAS (8995301)
GO:0016020	membrane	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005244	voltage-gated ion channel activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0015272	ATP-activated inward rectifier potassium channel activity	Molecular Function	TAS (8995301)
GO:0030955	potassium ion binding	Molecular Function	IEA
GO:0006811	ion transport	Biological Process	IEA
GO:0006813	potassium ion transport	Biological Process	TAS (8995301)